There were some villans of spiderman that were not exactly full time villans, i guess you could say. But they gave him the fight of his life. For example spider-man once had to help stop wolverine when he was on a rampage. That was a fight that he definitely did not walk out of unscathed. He also had a encounter with loki. Also one of the first villans he ever tangoed with was the chameleon. With my personal prefernce, i would of taken out the lizard and replaced him with the kingpin.