Let's look at our most likely candidates. John Goodman is big and has a great sense of humor, but then again Wayne Knight can also cast a great Peter if you make him taller. Kevin James might work, but he's too serious and thin. John Goodman would probably make a better Homer Simpson than Peter Griffin, though. Adam Sandler is a good Quagmire. Patrica Heaton can be Lois, Bill Murray might fit in there somewhere. Carl Weathers as Cleveland, and Arnold Schwarzenegger as Joe. Think about it.